tert-butyl ((4-(3-chlorophenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamate - Names and Identifiers
tert-butyl ((4-(3-chlorophenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamate - Introduction
tert-butyl ((4-(3-chroophenyl) tetrahydro-2H-pyran-4-yl)methyl)carbamate is an organic compound with the chemical formula C18H25ClNO3.
Nature:
-Appearance: Colorless to light yellow solid;
-Melting point: 76-77 ° C;
-Boiling Point: 399.4 ° C;
-Molecular weight: 339.85g/mol.
Use:
- tert-butyl ((4-(3-chlorophenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamate is commonly used as a pesticide intermediate for the synthesis of other pesticides;
-It can also be used as a lead compound for the synthesis of various organic heterocyclic compounds.
Method:
The synthesis of tert-butyl ((4-(3-chlorophenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamate can be achieved by the following steps:
1. Taking Tetrahydropyran as solvent, sodium hydroxide (NaOH) solution reacts with t-butyl carbonate (t-butyl carbonate) at low temperature to produce T-butoxide sodium salt (t-butyl);
2. Reacting the sodium tert-butoxide with chlorobenzene to synthesize ((4-(3-chlorophenyl) tetrahydro-2H-pyran-4-yl) methyl) alcohol;
3. Next, a certain amount of methylamine (methylamine) and excess hydrochloric acid (HCl) are added to methanol to obtain ((4-(3-chlorophenyl)) tetrahydro-2H-pyran-4-yl) methyl) methylamine hydrochloride;
4. Finally, a certain amount of trimethylchlorosilane (dimethylchlorosilane) is added with chloroform, and the reaction is completed under suitable conditions to generate the target product tert-butyl (4-(3-chlorophenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamate.
Safety Information:
tert-butyl ((4-(3-chroophenyl) tetrahydro-2H-pyran-4-yl)methyl)carbamate is an organic compound and should be handled with caution. Contact with skin and eyes may cause irritation and direct contact should be avoided. Appropriate protective equipment such as safety glasses, gloves and laboratory coats should be worn during operation. Safety procedures should be followed during use and ensure that it is carried out in a well-ventilated environment. If you are poisoned or unwell by accident, seek medical attention in time.
Last Update：2024-04-10 22:29:15